Alzheimer’s disease (AD), the leading cause of dementia, is characterized by cerebral amyloid-beta and tau deposition, impairing cognition. While cardiovascular diseases exacerbate AD, the reverse association is underappreciated. This systematic review examined clinical and experimental studies that explored the cardiogenic dementia hypothesis and mechanisms by which amyloidosis in AD contributes to cardiovascular complications. A review of PubMed, Ovid Embase/Medline, and CINAHL conducted in August 2024 identified 252 studies meeting the selection criteria. The findings highlight that AD-associated amyloidosis may have direct effects on the cardiovascular system, suggesting a bidirectional relationship between cardiac and neurological health that warrants further investigation.