GLP-1

Cardioprotection via brain-gut-heart signalling: GLP-1 activates KATP channels in coronary pericytes

Coronary no-reflow, which impacts roughly half of patients following artery reopening for myocardial infarction, remains a major clinical challenge. Here we demonstrate that the incretin GLP-1 (glucagon-like peptide 1) can be used to protect the …

Glucagon-Like Peptide-1 Links Ingestion, Homeostasis, and the Heart

Glucagon-like peptide-1 (GLP-1) is a gut hormone that plays critical roles in linking ingestion, metabolic homeostasis, and cardiovascular function. Endogenous peripheral GLP-1 exerts its effects either in a paracrine or endocrine fashion, or via …