Glucagon-like peptide-1 (GLP-1) is a gut hormone that plays critical roles in linking ingestion, metabolic homeostasis, and cardiovascular function. Endogenous peripheral GLP-1 exerts its effects either in a paracrine or endocrine fashion, or via …
BACKGROUND. Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is generally considered to be …
AIMS. Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of …