Myocardial Infarction

Cardioprotection via brain-gut-heart signalling: GLP-1 activates KATP channels in coronary pericytes

Coronary no-reflow, which impacts roughly half of patients following artery reopening for myocardial infarction, remains a major clinical challenge. Here we demonstrate that the incretin GLP-1 (glucagon-like peptide 1) can be used to protect the …

Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning

AIMS. Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of …