Role of muscarinic and nitric oxide dependent mechanisms in cardioprotection established by remote ischaemic preconditioning

Abstract

We demostrated a crucial dependence of RPc cardioprotection against ischaemia/reperfusion injury upon vagal innervation of the heart, and suggest that the ventricular muscarinic parasympathetic innervation and nitric oxide-dependent mechanisms are recruited. Cardioprotection induced by RPc may be achieved by actions of acetylcholine and nitric oxide released by vagal efferent fibers.

Date
Aug 31, 2013
Svetlana Mastitskaya
Svetlana Mastitskaya
Research Associate

My research interests include neural mechnisms of cardioprotection, functional interactions between the brain, the heart and the gut, and how these interactions are coordinated by the vagus nerve matter.