Svetlana is a Research Associate at the Department of Medical Physics and Biomedical Engineering, University College London. Her research interests include neural mechnisms of cardioprotection, functional interactions between the brain, the heart and the gut, and how these interactions are coordinated by the vagus nerve.
PhD in Cell Biology, 2009
Belarusian Medical Academy for Post-Graduate Education
MSc in Immunology, 2003
International Sakharov Environmental University
Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed tomography (microCT) and histology with fluorescent dextran tracers.
This study showed that optogenetic stimulation of vagal pre-ganglionic neurons transduced to express light-sensitive channels preserved left ventricular function and exercise capacity in a rat model of myocardial infarction−induced heart failure.
This study shows that cardiorespiratory reflexes maintain autonomic balance and ensure cardiovascular health. Impaired baroreflex may contribute to the development of cardiovascular disease and serves as a robust predictor of cardiovascular and all-cause mortality. The data obtained in this study suggest that astrocytes are integral components of the brainstem mechanisms that process afferent information and modulate baroreflex sensitivity via the release of ATP.
In the brain, after stroke, a similar post-ischaemic ‘no-reflow’ has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, followed by reperfusion, blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region.
This study demonstrates a crucial dependence of remote ischaemic preconditioning cardioprotection against ischaemia/reperfusion injury upon the activity of a distinct population of vagal pre-ganglionic neurones.