Vagal tone has long been associated with cardiac health. Recently, we have demonstrated that cardioprotective action of vagus nerve is attributed to the neurones of the dorsal motor nucleus of the vagus (DMV). Optogenetic stimulation of DMV neurones …
Incretin hormone glucagon-like peptide-1 (GLP-1) plays an important role in control of glucose metabolism and energy homeostasis. GLP-1R agonists also have significant beneficial effects on cardiovascular system (including anti-inflammatory, …
Selective optogenetic recruitment of vagal C-fibre efferents was found to be sufficient to preserve exercise capacity in the pathophysiological context of heart failure developing after a myocardial infarction.
Homeostatic mechanisms maintain arterial blood pressure, blood volume and arterial blood gases within a narrow physiological range. One of the important sites in the brain involved in this regulation is the nucleus tractus solitarii (NTS) which …
We demostrated a crucial dependence of RPc cardioprotection against ischaemia/reperfusion injury upon vagal innervation of the heart, and suggest that the ventricular muscarinic parasympathetic innervation and nitric oxide-dependent mechanisms are …